Exploring the Nonenzymatic Origin of Duclauxin-like Natural Products.

ABSTRACT: Chemical-biological efforts to increase the diversity of duclauxin (1)-like molecules for medicinal chemistry purposes unveiled the reactivity of duclauxin (1) toward amines and alcohols. To expand the compound class, a semisynthetic strategy conjugating amines to duclauxin (1) was employed. Insights gained from this approach led to the hypothesis that certain duclauxin-like "natural products" such as talaromycesone B (2), bacillisporin G (3), xenoclauxin (4), bacillisporins F (5/6), bacillisporins J (8/9), bacillisporins I (12/13), and verruculosin A (38) may be isolation artifacts rather than enzymatic products. Further experimentation, involving adsorption of 1 onto silica gel, resulted in

SUBMITTER: Aguilar-Ramirez E 

PROVIDER: S-EPMC11443492 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature