Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity.

ABSTRACT: This phytochemical study presents the isolation of eight alkaloids from Zephyranthes citrina Baker. The structures of the new alkaloids, zephycitrine (1) and 6-oxonarcissidine (2), were established by analysis of spectroscopic and spectrometric data. Processing the EtOH extract under acid-base conditions yielded the unreported isolation artifacts 3 and 4. This work also provides analytical data for alkaloids not properly described in the literature (5 and 6). The hippeastidine/zephyranine scaffolds in derivatives 3, 4, and 8-10 are also thoroughly discussed. Furthermore, a cytotoxicity screening of 25 Amaryllidaceae alkaloids isolated from Z. citrina was performed. Only the known alkaloids haemanthamine (

SUBMITTER: Kroustkova J 

PROVIDER: S-EPMC11443518 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature