Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes.

ABSTRACT:

Background

Occludin, a crucial component of tight junctions, has emerged as a promising biomarker for the diagnosis of acute ischemic disease, highlighting its significant potential in clinical applications. In the diabetes, Occludin serves as a downstream target gene intricately regulated by the adiponectin (APN) signaling pathway. However, the specific mechanism by which adiponectin regulates Occludin expression remains unclear.

Methods and results

Endothelial-specific Ocln knockdown reduced APN-mediated blood flow recovery after femoral artery ligation and nullified APN's protection against high-fat diet (HFD)-triggered apoptosis and angiogenesis inhibition in vivo. Mechanically, we have meticulously elucidated APN's regulatory role in Occludin expression through a compre

SUBMITTER: Duan Y 

PROVIDER: S-EPMC11443667 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature