CARD8 polymorphisms among bacterial meningitis patients in North-West Ethiopia.

ABSTRACT:

Background

The severity of infectious disease outcomes is dependent on the virulence factors of the pathogen and the host immune response. CARD8 is a major regulator of the innate immune proinflammatory response and has been suggested to modulate the host response to common inflammatory diseases. In the present study, the C10X genetic polymorphism in the CARD8 gene was investigated in relation to bacterial meningitis.

Methods

A total of 400 clinically suspected meningitis patients hospitalized at the University of Gondar Hospital were enrolled in the study. Cerebrospinal fluid (CSF) and blood samples were collected for laboratory investigations. The collected CSF was cultured, and all the results obtained from the culture were confirmed using direct RT‒PCR. Genotyping of who

SUBMITTER: Belayneh M 

PROVIDER: S-EPMC11443729 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature