Lambda light chain - restricted non - crystalline proximal tubulopathy with cast nephropathy in multiple myeloma: a case report and literature review.

ABSTRACT:

Background

Multiple myeloma (MM) often causes renal tubular damage, such as the light chain cast nephropathy (LCCN) and the light chain proximal tubulopathy (LCPT). The excessive light chains deposited in the proximal and distal tubules usually manifest with different characteristics, leading to a rare coexistence of the two pathological conditions. Here we report a unique case of a patient with multiple myeloma (MM) who presented with acute kidney injury (AKI) due to dual conditions of λ light chain-restricted non-crystalline LCPT and LCCN. This report reviews the clinical presentation and histological findings, comparing them with previously published cases.

Case presentation

A 49-year-old male patient was admitted with a chief complaint of "fatigue, loss of appetite for 4

SUBMITTER: Lan M 

PROVIDER: S-EPMC11443757 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature