Identification of necroptosis genes and characterization of immune infiltration in non-alcoholic steatohepatitis.

ABSTRACT:

Background

The most common progressive form of non-alcoholic fatty liver disease (NAFLD) is non-alcoholic steatohepatitis (NASH), which is characterized by the development of cirrhosis, and requires liver transplantation. We screened for the differentially expressed necroptosis-related genes in NASH in this study, and analyzed immune infiltration through microarray and bioinformatics analysis to identify potential biomarkers, and explore the molecular mechanisms involved in NASH.

Methods

The GSE24807 microarray dataset of NASH patients and healthy controls was downloaded, and we identified the differentially expressed genes (DEGs). Necroptosis-related differential genes (NRDEGs) were extracted from these DEGs, and functionally annotated by enrichment analyses. The core genes

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11443769 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature