Assessing the limitations of relief-based algorithms in detecting higher-order interactions.

ABSTRACT:

Background

Epistasis, the interaction between genetic loci where the effect of one locus is influenced by one or more other loci, plays a crucial role in the genetic architecture of complex traits. However, as the number of loci considered increases, the investigation of epistasis becomes exponentially more complex, making the selection of key features vital for effective downstream analyses. Relief-Based Algorithms (RBAs) are often employed for this purpose due to their reputation as "interaction-sensitive" algorithms and uniquely non-exhaustive approach. However, the limitations of RBAs in detecting interactions, particularly those involving multiple loci, have not been thoroughly defined. This study seeks to address this gap by evaluating the efficiency of RBAs in detecting high

SUBMITTER: Freda PJ 

PROVIDER: S-EPMC11443793 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature