Characterization of regeneration initiating cells during Xenopus laevis tail regeneration.

ABSTRACT:

Background

Embryos are regeneration and wound healing masters. They rapidly close wounds and scarlessly remodel and regenerate injured tissue. Regeneration has been extensively studied in many animal models using new tools such as single-cell analysis. However, until now, they have been based primarily on experiments assessing from 1 day post injury.

Results

In this paper, we reveal that critical steps initiating regeneration occur within hours after injury. We discovered the regeneration initiating cells (RICs) using single-cell and spatial transcriptomics of the regenerating Xenopus laevis tail. RICs are formed transiently from the basal epidermal cells, and their expression signature suggests they are important for modifying the surrounding extracellular matrix thus regul

SUBMITTER: Sindelka R 

PROVIDER: S-EPMC11443866 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature