Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification.

ABSTRACT:

Backgrounds

Acute transplant rejection is a major component of poor prognoses for organ transplantation. Owing to the multiple complex mechanisms involved, new treatments are still under exploration. Endometrial regenerative cells (ERCs) have been widely used in various refractory immune-related diseases, but the role of ERC-derived exosomes (ERC-Exos) in alleviating transplant rejection has not been extensively studied. Signaling lymphocyte activation molecule family 6 (SLAMF6) plays an important role in regulating immune responses. In this study, we explored the main mechanism by which ERC-Exos loaded with siSLAMF6 can alleviate allogeneic transplant rejection.

Methods

C57BL/6 mouse recipients of BALB/c mouse kidney transplants were randomly divided into four groups and tr

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11443917 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature