Role of histopathological, serological and molecular findings for the early diagnosis of treatment failure in leprosy.

ABSTRACT:

Background

Treatment failure (TF) in leprosy following multidrug therapy (MDT) presents a significant challenge. The current World Health Organization (WHO) fixed-duration MDT regimen, based on lesion count, might not be adequate. Leprosy lacks clear-cut objective cure criteria, and the predictive value of post-MDT histopathological findings remains uncertain. This study aims to identify predictive factors for TF among leprosy patients who have completed the WHO-recommended MDT.

Methods

An analysis was conducted on 80 individuals from a national leprosy reference center, comprising 40 TF cases (with a mean relapse at 13.0 months) and 40 controls (with a mean of 113.1 months without disease signs). Various epidemiological and clinical-laboratory parameters were assessed post-

SUBMITTER: de Carvalho Dornelas B 

PROVIDER: S-EPMC11443919 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature