DEFB119 stratifies dysbiosis with distorted networks in the seminal microbiome associated with male infertility.

ABSTRACT: Infertility is associated with the alteration of the seminal microbiome. However, the onset of dysbiosis remains controversial and the involvement of host factors remains elusive. This study investigates the alterations of the seminal microbiome in male infertility and examines the association and function of DEFB119, a reproductive-tract-specific host antimicrobial peptide, on the seminal microbiome and male fertility. While we observed comparable genera, diversity and evenness of bacterial communities, a marked decrease in the modularity of the metacommunities was observed in patients with abnormal spermiogram (n = 57) as compared to the control (n = 30). A marked elevation of DEFB119 was observed in a subpopulation of male infertile patients (n = 5). Elevated semina

SUBMITTER: Jin J 

PROVIDER: S-EPMC11443970 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature