Widespread natural selection on metabolite levels in humans.

ABSTRACT: Natural selection acts ubiquitously on complex human traits, predominantly constraining the occurrence of extreme phenotypes (stabilizing selection). These constraints propagate to DNA sequence variants associated with traits under selection. The genetic signatures of such evolutionary events can thus be detected via combining effect size estimates from genetic association studies and the corresponding allele frequencies. Although this approach has been successfully applied to high-level traits, the prevalence and mode of selection acting on molecular traits remain poorly understood. Here, we estimate the action of natural selection on genetic variants associated with metabolite levels, an important layer of molecular traits. By leveraging summary statistics of published genome-wide associ

SUBMITTER: Timasheva Y 

PROVIDER: S-EPMC11444169 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature