The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report.

ABSTRACT: Conscious reportability of visual input is associated with a bimodal neural response in the primary visual cortex (V1): an early-latency response coupled to stimulus features and a late-latency response coupled to stimulus report or detection. This late wave of activity, central to major theories of consciousness, is thought to be driven by the prefrontal cortex (PFC), responsible for "igniting" it. Here we analyzed two electrophysiological studies in mice performing different stimulus detection tasks and characterized neural activity profiles in three key cortical regions: V1, posterior parietal cortex (PPC), and PFC. We then developed a minimal network model, constrained by known connectivity between these regions, reproducing the spatiotemporal propagation of visual- and report-related

SUBMITTER: Ciceri S 

PROVIDER: S-EPMC11444237 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature