Diffusion Analyses along Mean and Gaussian-Curved Membranes with CurD.

ABSTRACT: Curved cellular membranes are both abundant and functionally relevant. While novel tomography approaches reveal the structural details of curved membranes, their dynamics pose an experimental challenge. Curvature especially affects the diffusion of lipids and macromolecules, yet neither experiments nor continuum models distinguish geometric effects from those caused by curvature-induced changes in membrane properties. Molecular simulations could excel here, yet despite community interest toward curved membranes, tools for their analysis are still lacking. Here, we satisfy this demand by introducing CurD, our novel and openly available implementation of the Vertex-oriented Triangle Propagation algorithm to the study of lipid diffusion along membranes with mean and/or Gaussian curvature. Thi

SUBMITTER: Fabian B 

PROVIDER: S-EPMC11444424 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature