Early B lymphocyte subsets in blood predict prognosis in sepsis.

ABSTRACT:

Background

B lymphocytes play a key role in immunosuppression. This study investigated the prognostic value of B cell subsets in sepsis.

Methods

Flow cytometry was used to assess peripheral B cell subsets from patients with sepsis on the first and seventh days following admission, as well as 111 healthy controls. The patients were divided into survivors and non-survivors, based on 28-day prognosis.

Results

The analysis showed abnormal distribution and selective depletion of B cells and its subsets in the early stages of sepsis. On day 1, compared with survivors, non-survivors showed significant decreases in the proportion and absolute count of transitional (Tr) B cells, reductions in the proportion of CD5⁺ B cells, and increases in the proportion of double-

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11445034 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature