Emodin repairs interstitial cells of Cajal damaged by cholelithiasis in the gallbladder.

ABSTRACT:

Background

Hypercholesterolemia induces cholelithiasis and dysfunction of gallbladder motility. Interstitial cells of Cajal (ICCs) contribute to gallbladder motility. Emodin modulates the contractility of the gallbladder muscle; however, the underlying mechanism is unknown.

Aim

This study aimed to explore the effects of emodin on gallbladder ICCs with cholelithiasis in a guinea pig model.

Methods

Animals were randomly divided into a healthy control group and three study groups. All study groups received a high-cholesterol diet (HCD) for 8 weeks. Subsequently, they were randomly assigned to either the HCD group or one of the emodin treatment groups lasting 4 or 8 weeks. Total cholesterol (TC) and triglycerides (TG) were measured to determine changes in serum lipid leve

SUBMITTER: Huang ZP 

PROVIDER: S-EPMC11445038 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature