Cytomegalovirus results in poor graft function via bone marrow-derived endothelial progenitor cells.

ABSTRACT:

Introduction

Poor graft function (PGF), characterized by myelosuppression, represents a significant challenge following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with human cytomegalovirus (HCMV) being established as a risk factor for PGF. However, the underlying mechanism remains unclear. Bone marrow endothelial progenitor cells (BM-EPCs) play an important role in supporting hematopoiesis and their dysfunction contributes to PGF development. We aim to explore the effects of CMV on BM-EPCs and its underlying mechanism.

Methods

We investigated the compromised functionality of EPCs derived from individuals diagnosed with HCMV viremia accompanied by PGF, as well as after infected by HCMV AD 169 strain in vitro, characterized by decreased cell prolife

SUBMITTER: Lv W 

PROVIDER: S-EPMC11445044 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature