Longitudinal associations between microRNAs and weight in the diabetes prevention program.

ABSTRACT:

Objective

Circulating microRNAs show cross-sectional associations with overweight and obesity. Few studies provided data to differentiate between a snapshot perspective on these associations versus how microRNAs characterize prodromal risk from disease pathology and complications. This study assessed longitudinal relationships between circulating microRNAs and weight at multiple time-points in the Diabetes Prevention Program trial.

Research design and methods

A subset of participants (n=150) from the Diabetes Prevention Program were included. MicroRNAs were measured from banked plasma using a Fireplex Assay. We used generalized linear mixed models to evaluate relationships between microRNAs and changes in weight at baseline, year-1, and year-2. Logistic regression was used t

SUBMITTER: Flowers E 

PROVIDER: S-EPMC11445047 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature