Gene co-expression networks reveal sex-biased differences in musculoskeletal ageing.

ABSTRACT: Aging is a universal and progressive process involving the deterioration of physiological functions and the accumulation of cellular damage. Gene regulation programs influence how phenotypes respond to environmental and intrinsic changes during aging. Although several factors, including sex, are known to impact this process, the underlying mechanisms remain incompletely understood. Here, we investigate the functional organization patterns of skeletal muscle genes across different sexes and ages using gene co-expression networks (GCNs) to explore their influence on aging. We constructed GCNs for three different age groups for male and female samples, analyzed topological similarities and differences, inferred significant associated processes for each network, and constructed null models to

SUBMITTER: Olascoaga S 

PROVIDER: S-EPMC11445131 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature