Mechanical force promotes tissue and molecular changes in adipose tissue regeneration post-transplantation.

ABSTRACT:

Introduction

Fat grafting often yields inconsistent and suboptimal results, necessitating improved fat processing techniques. A stromal vascular fraction (SVF) gel created using mechanical emulsification demonstrates superior retention rates to conventional Coleman fat grafts.

Methods

This study investigated the mechanisms at play by transplanting fat aspirates from liposuction patients-either processed as Coleman fat grafts or further refined into an SVF gel via mechanical shear force-onto the backs of nude mice.

Results

The retention rate of the SVF gel after transplantation surpassed that observed for Coleman fat. Hematoxylin and eosin (HE) staining and immunofluorescence results demonstrated that the SVF gel group could form new adipose tissue characterized by wel

SUBMITTER: Ye Y 

PROVIDER: S-EPMC11445162 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature