Metformin use and risk of myeloproliferative neoplasms: a Danish population-based case-control study.

ABSTRACT:

Abstract

Previous studies have suggested that metformin has beneficial effects beyond its glucose-lowering properties, particularly in terms of its potential as an antineoplastic and cancer-preventive agent. In this study, we aimed to investigate the association between metformin use and the risk of myeloproliferative neoplasms (MPN). We conducted a population-based case-control study using Danish registers. Cases with MPN diagnosed between 2010 and 2018 were identified, and metformin use before the MPN diagnosis was ascertained. We compared metformin use among cases with MPN and an age- and sex-matched control group from the Danish general population to estimate age- and sex-adjusted odds ratios (ORs) and fully adjusted ORs (aORs) for the association between metformin use and risk

SUBMITTER: Kristensen DT 

PROVIDER: S-EPMC11445222 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature