Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection.

ABSTRACT: IL-1β represents an important inflammatory factor involved in the host response against GBS infection. Prior research has suggested a potential involvement of IL-1β in the process of ferroptosis. However, the relationship between IL-1β and ferroptosis in the context of anti-GBS infection remains uncertain. This research demonstrates that the occurrence of ferroptosis is essential for the host's defense against GBS infection in a mouse model of abdominal infection, with peritoneal macrophages identified as the primary cells undergoing ferroptosis. Further research indicates that IL-1β induces lipid oxidation in macrophages through the upregulation of pathways related to lipid oxidation. Concurrently, IL-1β is not only involved in the initiation of ferroptosis in macrophages, but its product

SUBMITTER: Yi JX 

PROVIDER: S-EPMC11445261 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature