Quantitative evaluation of lesion response heterogeneity for superior prognostication of clinical outcome.

ABSTRACT:

Purpose

Standardized reporting of treatment response in oncology patients has traditionally relied on methods like RECIST, PERCIST and Deauville score. These endpoints assess only a few lesions, potentially overlooking the response heterogeneity of all disease. This study hypothesizes that comprehensive spatial-temporal evaluation of all individual lesions is necessary for superior prognostication of clinical outcome.

Methods

[¹⁸F]FDG PET/CT scans from 241 patients (127 diffuse large B-cell lymphoma (DLBCL) and 114 non-small cell lung cancer (NSCLC)) were retrospectively obtained at baseline and either during chemotherapy or post-chemoradiotherapy. An automated TRAQinform IQ software (AIQ Solutions) analyzed the images, performing quantification of change in regio

SUBMITTER: Lokre O 

PROVIDER: S-EPMC11445285 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature