Baseline [¹⁸F]FDG PET/CT and MRI first-order breast tumor features do not improve pathological complete response prediction to neoadjuvant chemotherapy.

ABSTRACT:

Purpose

To verify the ability of pretreatment [¹⁸F]FDG PET/CT and T1-weighed dynamic contrast-enhanced MRI to predict pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer (BC) patients.

Methods

This retrospective study includes patients with BC of no special type submitted to baseline [¹⁸F]FDG PET/CT, NAC and surgery. [¹⁸F]FDG PET-based features reflecting intensity and heterogeneity of tracer uptake were extracted from the primary BC and suspicious axillary lymph nodes (ALN), for comparative analysis related to NAC response (pCR vs. non-pCR). Multivariate logistic regression was performed for response prediction combining the breast tumor-extracted PET-based features and clinicopathological features. A s

SUBMITTER: Oliveira C 

PROVIDER: S-EPMC11445295 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature