Connectivity based on glucose dynamics reveals exaggerated sensorimotor network coupling on subject-level in Parkinson's disease.

ABSTRACT:

Purpose

While fMRI provides information on the temporal changes in blood oxygenation, 2- [18F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG)-PET has traditionally offered a static snapshot of brain glucose consumption. As a result, studies investigating metabolic brain networks as potential biomarkers for neurodegeneration have primarily been conducted at the group level. However, recent pioneering studies introduced time-resolved [¹⁸F]FDG-PET with constant infusion, which enables metabolic connectivity studies at the individual level.

Methods

In the current study, this technique was employed to explore Parkinson's disease (PD)-related alterations in individual metabolic connectivity, in comparison to inter-subject measures and hemodynamic connectivity. Fifteen PD

SUBMITTER: Ruppert-Junck MC 

PROVIDER: S-EPMC11445336 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature