Angiogenic properties and intercellular communication of differentiated porcine endothelial cells in vascular therapy.

ABSTRACT: Endothelial cell dysfunction can lead to various vascular diseases. Blood flow disorder is a common symptom of vascular diseases. Regenerative angiogenesis, which involves transplanting vascular cells or stem cells into the body to shape new vasculature, can be a good therapeutic strategy. However, there are several limitations to using autologous cells from the patients themselves. We sought to investigate the new vascular cells that can play a role in the formation of angiogenesis in vivo using stem cells from alternative animals suitable for cellular therapy. Porcine is an optimal animal model for xenotransplantation owing to its physiological similarity to humans. We used differentiated porcine endothelial cells (pECs) as a therapeutic strategy to restore vessel function. Differentiate

SUBMITTER: Seo BG 

PROVIDER: S-EPMC11445381 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature