TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells.

ABSTRACT: The release of Ca²⁺ ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation. This release of Ca²⁺ often occurs through inositol 1,4,5-triphosphate receptors and the activity of these channels and the levels of stored Ca²⁺ in the endoplasmic reticulum are important regulators of cell death in cancer cells. A recently identified Ca²⁺ channel of the endoplasmic reticulum is transmembrane and coiled-coil domains 1 (TMCO1). In this study, we link the overexpression of TMCO1 with prognosis in node-positive basal breast cancer patients. We also identify interacting proteins of TMCO1, which include endoplasmic reticulum-resident proteins involved in Ca

SUBMITTER: Bong AHL 

PROVIDER: S-EPMC11445413 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature