An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation.

ABSTRACT: To what extent and how post-transcriptional dysregulation affects aging proteome remains unclear. Here, we provide proteomic data of whole-tissue lysates (WTL) and low-solubility protein-enriched fractions (LSF) of major tissues collected from mice of 6, 15, 24, and 30 months of age. Low-solubility proteins are preferentially affected by age and the analysis of LSF doubles the number of proteins identified to be differentially expressed with age. Simultaneous analysis of proteome and transcriptome using the same tissue homogenates reveals the features of age-related post-transcriptional dysregulation. Post-transcriptional dysregulation becomes evident especially after 24 months of age and age-related post-transcriptional dysregulation leads to accumulation of core matrisome proteins and re

SUBMITTER: Takasugi M 

PROVIDER: S-EPMC11445428 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature