Local stimulation of pyramidal neurons in deep cortical layers of anesthetized rats enhances cortical visual information processing.

ABSTRACT: In the primary visual cortex area V1 activation of inhibitory interneurons, which provide negative feedback for excitatory pyramidal neurons, can improve visual response reliability and orientation selectivity. Moreover, optogenetic activation of one class of interneurons, parvalbumin (PV) positive cells, reduces the receptive field (RF) width. These data suggest that in V1 the negative feedback improves visual information processing. However, according to information theory, noise can limit information content in a signal, and to the best of our knowledge, in V1 signal-to-noise ratio (SNR) has never been estimated following either pyramidal or inhibitory neuron activation. Therefore, we optogenetically activated pyramidal or PV neurons in the deep layers of cortical area V1 and measured t

SUBMITTER: Baranauskas G 

PROVIDER: S-EPMC11445437 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature