Association between probable sarcopenia and dementia risk: a prospective cohort study with mediation analysis.

ABSTRACT: The role of alcohol consumption as a mediator in the risk between sarcopenia and dementia remains inadequately studied. There is currently limited research on whether the association between sarcopenia and the risk of Alzheimer's disease (AD) is influenced by genetic susceptibility. Our study incorporated a total of 483,637 baseline non-dementia participants, who were classified into groups of individuals with no sarcopenia and those with probable sarcopenia based on the definition. We employed Cox proportional hazards models to evaluate the association between probable sarcopenia and the risk of all cause dementia (ACD), AD, and vascular dementia (VD). We conducted mediation analysis to explore the role of alcohol consumption in the association between probable sarcopenia and the risk of

SUBMITTER: Ling Y 

PROVIDER: S-EPMC11445531 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature