Atg7 autophagy-independent role on governing neural stem cell fate could be potentially applied for regenerative medicine.

ABSTRACT: A literature review showed that Atg7 biological role was associated with the development and pathogenesis of nervous system, but very few reports focused on Atg7 role on neurogenesis at the region of spinal cord, so that we are committed to explore the subject. Atg7 expression in neural tube is incrementally increased during neurogenesis. Atg7 neural-specific knockout mice demonstrated the impaired motor function and imbalance of neuronal and glial cell differentiation during neurogenesis, which was similarly confirmed in primary neurosphere culture and reversely verified by Atg7 overexpression in unilateral neural tubes of gastrula chicken embryos. Furthermore, activating autophagy in neural stem cells (NSCs) of neurospheres did not rescue Atg7 deficiency-suppressed neuronal differentiati

SUBMITTER: Shen Y 

PROVIDER: S-EPMC11445561 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature