Evolutionarily conserved fMRI network dynamics in the mouse, macaque, and human brain.

ABSTRACT: Evolutionarily relevant networks have been previously described in several mammalian species using time-averaged analyses of fMRI time-series. However, fMRI network activity is highly dynamic and continually evolves over timescales of seconds. Whether the dynamic organization of resting-state fMRI network activity is conserved across mammalian species remains unclear. Using frame-wise clustering of fMRI time-series, we find that intrinsic fMRI network dynamics in awake male macaques and humans is characterized by recurrent transitions between a set of 4 dominant, neuroanatomically homologous fMRI coactivation modes (C-modes), three of which are also plausibly represented in the male rodent brain. Importantly, in all species C-modes exhibit species-invariant dynamic features, including pref

SUBMITTER: Gutierrez-Barragan D 

PROVIDER: S-EPMC11445567 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature