Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation.

ABSTRACT: Bone loss caused by long-duration spaceflight seriously affects the skeletal health of astronauts. There are many shortcomings in currently available treatments for weightlessness-induced bone loss. The aim of this study was to evaluate the preventive effect of Angelica dahuricae Radix (AR) on simulated microgravity-induced bone loss. Here, we established a hind limb unloading (HLU) mouse model and treated HLU mice with AR (2 g/kg) for 4 weeks. Results indicated that AR significantly inhibited simulated microgravity-induced bone loss. In addition, the components in AR were analyzed using UPLC-MS/MS; results showed that a total of 224 compounds were detected in AR, which mainly contained 7 classes of components. Moreover, the network pharmacological predictions suggested that active ingredi

SUBMITTER: Liang X 

PROVIDER: S-EPMC11445575 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature