Association between statin use and dry eye disease in patients with hyperlipidemia: A population-based retrospective cohort study.

ABSTRACT: Higher serum cholesterol levels have been associated with an increased risk of dry eye disease (DED). The relationship between statin (HMG-CoA reductase inhibitor) use and DED in patients with hyperlipidemia remains unclear. To investigate the association between statin use and the risk of DED in patients with hyperlipidemia, we conducted a population-based retrospective cohort study utilizing data from Taiwan's Longitudinal Generation Tracking Database. Patients were categorized into statin users and nonusers, with a 5-year follow-up period. The study identified patients with newly diagnosed hyperlipidemia, excluding those with prior DED diagnoses. Matching and adjustments for covariates resulted in 41,931 individuals in each group. Patients receiving statin therapy were compared with tho

SUBMITTER: Wang YW 

PROVIDER: S-EPMC11445710 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature