Synthesis, Characterization, and Biological Evaluation of Novel [M(η⁶-arene)₂]⁺ (M = Re, ^99mTc) Hosted Terpyridines and Copper Complexes Thereof.

ABSTRACT: We report the synthesis, characterization, and in vitro biological activities of [Re(η⁶-arene)₂]⁺-terpyridine conjugates and their Cu^II complexes. The terpyridine (terpy) chelators were attached to the [Re(η⁶-arene)₂]⁺ scaffold via secondary amine linkers allowing for heteroleptic mono- and homoleptic bis-terpyridine-substituted chelators. Complexation with CuCl₂ afforded the respective square pyramidal [Cu(terpy)Cl₂] complexes hosted on the [Re(η⁶-arene)₂]⁺ scaffold. The chelator conjugates and their respective complexes were found to be remarkably cytotoxic against malignant HT29 and A549 human cancer cell lines in vitro with IC₅₀ values in the lo

SUBMITTER: Csucker J 

PROVIDER: S-EPMC11445722 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature