Macrophages allocate before apoptosis initiation and produce reactive oxygen species during interdigital phagocytosis.

ABSTRACT: During programmed cell death (PCD), it is commonly accepted that macrophages are recruited by apoptotic cells to complete cell degradation. Interdigital cell death, a classical model of PCD, contributes to digit individualization in limbs of mammals and other vertebrates. Here, we show that macrophages are present in interdigits before significant cell death occurs and remain after apoptosis inhibition. The typical interdigital phagocytic activity was not observed after a partial depletion of macrophages and was markedly reduced by engulfment/phagosome maturation inhibition, as detected by its association with high lysosomal activity. β-galactosidase activity in this region was also coupled with phagocytosis, against its relationship with cellular senescence. Interdigital phagocytosis corr

SUBMITTER: Hernandez-Garcia D 

PROVIDER: S-EPMC11445842 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature