Genetics of hip dysplasia - a systematic literature review.

ABSTRACT:

Background

Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all newborns. DDH increases the risk of osteoarthritis and is the cause of 30% of all total hip arthroplasties in adults < 40 years of age. We aim to explore the genetic background of DDH in order to improve diagnosis and personalize treatment.

Methods

We conducted a structured literature review using PRISMA guidelines searching the Medline, Embase and Cochrane databases. We included 31 case control studies examining single nucleotide polymorphisms (SNPs) in non-syndromic DDH.

Results

A total of 73 papers were included for full text review, of which 31 were single nucleotide polymorphism (SNP) case/control association studies. The literature review revealed that the majorit

SUBMITTER: Jacobsen KK 

PROVIDER: S-EPMC11445845 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature