Synergistic activity of <i>Enterococcus Faeciu</i>m-induced ferroptosis via expansion of IFN-γ⁺CD8⁺ T cell population in advanced hepatocellular carcinoma treated with sorafenib.

ABSTRACT: The gut microbiota plays an important role in the development and treatment of hepatocellular carcinoma (HCC). However, the implication of specific gut microbiota in targeted sorafenib therapy for advanced HCC and the microbiota mode of action, remain to be elucidated. Here, we confirmed that four bacterial genera, Lachnoclostridium, Lachnospira, Enterobacter and Enterococcus, are associated with the therapeutic efficacy of Sorafenib, and that Enterobacter faecium (Efm) plays a crucial role in modulating the sorafenib activity. The effective colonization by Emf induced the IL-12 and IFN-γ production and an increased proportion of IFN-γ⁺CD8⁺ T cells in the tumor microenvironment. Finally, exopolysaccharides (EPS) from Efm were the pri

SUBMITTER: Yu H 

PROVIDER: S-EPMC11445893 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature