Paclitaxel chemotherapy disrupts microbiota-enterohepatic bile acid metabolism in mice.

ABSTRACT: Balanced interactions between the enteric microbiota and enterohepatic organs are essential to bile acid homeostasis, and thus normal gastrointestinal function. Disruption of these interactions by cancer treatment instigates bile acid malabsorption, leading to treatment delays, malnutrition, and decreased quality of life. However, the nature of chemotherapy-induced bile acid malabsorption remains poorly characterized with limited treatment options. Therefore, this study sought to characterize changes in hepatic, enteric, and microbial bile acid metabolism in a mouse model of chemotherapy-induced toxicity. Consistent with clinical bile acid malabsorption, chemotherapy increased fecal excretion of primary bile acids and water, while diminishing microbiome diversity, secondary bile acid forma

SUBMITTER: Loman BR 

PROVIDER: S-EPMC11445932 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature