Identification of SLC22A17 DNA methylation hotspot as a potential biomarker in cutaneous melanoma.

ABSTRACT:

Background

Cancer onset and progression are driven by genetic and epigenetic alterations leading to oncogene activation and the silencing of tumor suppressor genes. Among epigenetic mechanisms, DNA methylation (methDNA) is gaining growing interest in cancer. Promoter hypomethylation is associated with oncogene activation while intragenic methDNA can be involved in transcriptional elongation, alternative spicing, and the activation of cryptic start sites. Several genes involved in the modulation of the tumor microenvironment are regulated by methDNA, including the Solute Carrier Family 22 Member 17 (SLC22A17), which is involved in iron trafficking and extracellular matrix remodeling cooperating with the Gelatinase-Associated Lipocalin (NGAL) ligand. However, the exact role of intrag

SUBMITTER: Lavoro A 

PROVIDER: S-EPMC11445995 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature