Human IL-22 receptor-targeted small protein antagonist suppress murine DSS-induced colitis.

ABSTRACT:

Background

Human interleukin-22 (IL-22) is known as a "dual function" cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against bacterial pathogens. On the other hand, the overexpression of IL-22 is associated with hyper-proliferation and recruitment of pathologic effector cells, leading to tissue damage and chronic inflammation in specific diseases including inflammatory bowel disease (IBD). To study a role of IL-22-mediated signaling axis during intestinal inflammation, we generated a set of small protein blockers of IL-22R1 and verified their inhibitory potential on murine model of colitis.

Methods

We used directed evolution of proteins to identify binders of human IL-22 receptor alph

SUBMITTER: Kuchar M 

PROVIDER: S-EPMC11446014 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature