Creatinine clearance/eGFR ratio: a simple index for muscle mass related to mortality in ICU patients.

ABSTRACT:

Introduction

In patients admitted to the intensive care unit (ICU), muscle mass is inversely associated with mortality. Although muscle mass can be estimated with 24-h urinary creatinine excretion (UCE), its use for risk prediction in individual patients is limited because age-, sex-, weight- and length-specific reference values for UCE are lacking. The ratio between measured creatinine clearance (mCC) and estimated glomerular filtration rate (eGFR) might circumvent this constraint. The main goal was to assess the association of the mCC/eGFR ratio in ICU patients with all-cause hospital and long-term mortality.

Methods

The mCC/eGFR ratio was determined in patients admitted to our ICU between 2005 and 2021 with KDIGO acute kidney injury (AKI) stage 0-2 and an ICU stay ≥ 24 h.

SUBMITTER: Volbeda M 

PROVIDER: S-EPMC11446022 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature