Investigation of in vitro susceptibility and resistance mechanisms to amikacin among diverse carbapenemase-producing Enterobacteriaceae.

ABSTRACT:

Objective

This study aims to assess the in vitro drug susceptibility of various Carbapenemase-Producing Enterobacteriaceae (CPE) genotypes and elucidate the underlying mechanisms of amikacin resistance.

Methods

A total of 72 unique CPE strains were collected from the Second Hospital of Jiaxing between 2019 and 2022, including 51 strains of Klebsiella pneumoniae, 11 strains of Escherichia coli, 6 strains of Enterobacter cloacae, 2 strains of Klebsiella aerogenes, 1 strain of Citrobacter freundii, and 1strain of Citrobacter werkmanii. Among these strains, 24 carried bla_KPC gene, 20 carried bla_NDM gene, 23 carried bla_OXA-48-like gene, and 5 carried both bla_KPC and bla_NDM. We measured the in vitro activity of amikacin and ot

SUBMITTER: Wu X 

PROVIDER: S-EPMC11446084 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature