Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea.

ABSTRACT:

Study objectives

Excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea is poorly explained by standard clinical sleep architecture metrics. We hypothesized that reduced sleep stage continuity mediates this connection independently from standard sleep architecture metrics.

Methods

A total of 1,907 patients with suspected obstructive sleep apnea with daytime sleepiness complaints underwent in-lab diagnostic polysomnography and next-day Multiple Sleep Latency Test. Sleep architecture was evaluated with novel sleep-stage continuity quantifications (mean sleep stage duration and probability of remaining in each sleep stage), and conventional metrics (total non-rapid eye movement stages 1, 2, 3 (N1, N2, N3) and rapid eye movement times; and sleep onset latenc

SUBMITTER: Chen X 

PROVIDER: S-EPMC11446124 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature