Maternal early pregnancy body mass index and risk of sleep apnea in the offspring.

ABSTRACT:

Study objectives

We investigated the association between maternal early pregnancy body mass index (BMI) and offspring sleep apnea diagnosis.

Methods

We conducted a nationwide cohort study among 3,281,803 singleton live births in Sweden born 1983-2015. Using national registers with prospectively recorded information, we followed participants for a sleep apnea diagnosis from 2 to up to 35 years of age. We compared sleep apnea risks by early pregnancy BMI categories using hazard ratios with 95% confidence intervals from adjusted Cox models. To address confounding by factors shared within families, we conducted sibling-controlled analyses and studied the relation of siblings' maternal BMI with index offspring's sleep apnea risk.

Results

There were 17,830 sleep apnea diagn

SUBMITTER: Zhu MQ 

PROVIDER: S-EPMC11446132 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature