Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder.

ABSTRACT: The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD) are not well understood. Using a large neuroimaging dataset, we identified three latent dimensions of functional brain network connectivity that predicted individual differences in ASD behaviors and were stable in cross-validation. Clustering along these three dimensions revealed four reproducible ASD subgroups with distinct functional connectivity alterations in ASD-related networks and clinical symptom profiles that were reproducible in an independent sample. By integrating neuroimaging data with normative gene expression data from two independent transcriptomic atlases, we found that within each subgroup, ASD-related functional connectivity was explained by regional differences in the expression of dist

SUBMITTER: Buch AM 

PROVIDER: S-EPMC11446249 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature