Automated optimization of TMS coil placement for personalized functional network engagement.

ABSTRACT: Transcranial magnetic stimulation (TMS) is used to treat multiple psychiatric and neurological conditions by manipulating activity in particular brain networks and circuits, but individual responses are highly variable. In clinical settings, TMS coil placement is typically based on either group average functional maps or scalp heuristics. Here, we found that this approach can inadvertently target different functional networks in depressed patients due to variability in their functional brain organization. More precise TMS targeting should be feasible by accounting for each patient's unique functional neuroanatomy. To this end, we developed a targeting approach, termed targeted functional network stimulation (TANS). The TANS approach improved stimulation specificity in silico in 8 highly sa

SUBMITTER: Lynch CJ 

PROVIDER: S-EPMC11446252 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature