Large expansion of plasma commensal viruses is associated with SIV pathogenesis in Macaca leonina.

ABSTRACT: Human immunodeficiency virus-1 (HIV-1) infection disrupts the homeostatic equilibrium between the host and commensal microbes. However, the dynamic changes of plasma commensal viruses and their role in HIV/simian immunodeficiency virus (SIV) pathogenesis are rarely reported. Here, we investigated the longitudinal changes of plasma virome, inflammation levels, and disease markers using an SIV-infected Macaca leonina model. Large expansions of plasma Anelloviridae, Parvoviridae, Circoviridae and other commensal viruses, and elevated levels of inflammation and D-dimer were observed since the chronic phase of SIV infection. Anelloviridae abundance appears to correlate positively with the CD4⁺ T cell count but negatively with SIV load especially at

SUBMITTER: Li Y 

PROVIDER: S-EPMC11446265 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature