Evaluation of the fish acute toxicity test for pesticide registration.

ABSTRACT: The U.S. Environmental Protection Agency (USEPA) uses the in vivo fish acute toxicity test to assess potential risk of substances to non-target aquatic vertebrates. The test is typically conducted on a cold and a warm freshwater species and a saltwater species for a conventional pesticide registration, potentially requiring upwards of 200 or more fish. A retrospective data evaluation was conducted to explore the potential for using fewer fish species to support conventional pesticide risk assessments. Lethal concentration 50% (LC₅₀) values and experimental details were extracted and curated from 718 studies on fish acute toxicity submitted to USEPA. The LC₅₀ data were analysed to determine, when possible, the relative sensitivity of the tested species to each pesticid

SUBMITTER: Ceger P 

PROVIDER: S-EPMC11446266 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature