Neuroinflammation as a cause of differential Muller cell regenerative responses to retinal injury.

ABSTRACT: Unlike mammals, some nonmammalian species recruit Müller glia for retinal regeneration after injury. Identifying the underlying mechanisms may help to foresee regenerative medicine strategies. Using a Xenopus model of retinitis pigmentosa, we found that Müller cells actively proliferate upon photoreceptor degeneration in old tadpoles but not in younger ones. Differences in the inflammatory microenvironment emerged as an explanation for such stage dependency. Functional analyses revealed that enhancing neuroinflammation is sufficient to trigger Müller cell proliferation, not only in young tadpoles but also in mice. In addition, we showed that microglia are absolutely required for the response of mouse Müller cells to mitogenic factors while negatively affecting their neurogenic poten

SUBMITTER: Garcia-Garcia D 

PROVIDER: S-EPMC11446274 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature